Article

LPS-induced extracellular AREG triggers macrophages pyroptosis through EGFR/TLR4 signaling pathway

2025-01-06

Abstract excerpt

<title>Abstract</title> <p>Amphiregulin (AREG), as another EGF family member, is anchored to the cell surface as a transmembrane protein. In response to external stimulus, its extracellular domain can be release to extracellular matrix in a paracrine or autocrine manner. However, what it plays in septic macrophages pyroptosis remain poorly understood. The role of extracellular AREG was investigated in septic macr...

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Literature Corpus work: cebe6af9-a903-5cc5-bac0-0312fcf5c30b
DOI: 10.21203/rs.3.rs-5743694/v1

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