Article

Acalabrutinib May Offer a New Therapeutic Approach for Consolidation and Maintenance of Primary CNS Lymphoma with Expression of MYD88 and CD79B Gene Variants: A Case Report and Literature Review of Primary CNS Lymphoma in the BTKi Era

2025-08-28

Abstract excerpt

We present the case of a patient with Primary CNS Lymphoma (PCNSL), with MYD88 and CD79B gene variants, that was unable to complete standard induction and consolidation treatment due to toxicity and co-morbidities after 3 cycles of MATRix. Though he had responded to truncated induction, acalabrutinib, the BTK inhibitor, was used in an attempt to consolidate and maintain his response. He has an ongoing remission at...

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Literature Corpus work: cd8f688c-5494-54da-9bb8-a4850f709c5f
DOI: 10.20944/preprints202508.2027.v1

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Acalabrutinib May Offer a New Therapeutic Approach for Consolidation and Maintenance of Primary CNS Lymphoma with Expression of MYD88 and CD79B Gene Variants: A Case Report and Literature Review of Primary CNS Lymphoma in the BTKi EraDOI 10.20944/preprints202508.2027.v1Read

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