Article

Evidence that minocycline treatment confounds the interpretation of neurofilament as a biomarker

2024-05-02

Abstract excerpt

Neurofilament light (NfL) concentration in cerebrospinal fluid (CSF) and blood serves as an important biomarker in neurology drug development. Changes in NfL are generally assumed to reflect changes in neuronal damage, while little is known about the clearance of NfL from biofluids. We observed an NfL increase of 3.5-fold in plasma and 5.7-fold in CSF in an asymptomatic individual at risk for genetic prion disease...

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Literature Corpus work: cd27293b-4b10-524a-9d87-819459e33206
DOI: 10.1101/2024.05.01.24306384

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