Article

Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF

2024-05-17

Abstract excerpt

Left ventricular (LV) longitudinal function is mechanically coupled to the elasticity of the ascending aorta (AA). The pathophysiologic link between stiff AA and reduced longitudinal strain and subsequent deterioration in longitudinal LV systolic function is likely relevant in heart failure with preserved ejection fraction (HFpEF). A proposed therapeutic effect of freeing the LV apex and allowing for LV inverse lo...

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Literature Corpus work: cc728fbe-8ac0-5c01-a532-c500e7cd395e
DOI: 10.20944/preprints202405.1155.v1

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