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Article

Biomechanics of diastolic dysfunction: a one-dimensional computational modeling approach.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2020

Kadry Karim, Pagoulatou Stamatia, Mercier Quentin, Rovas Georgios, Bikia Vasiliki, Müller Hajo, Adamopoulos Dionysios, Stergiopulos Nikolaos

Abstract excerpt

Diastolic dysfunction (DD) is a major component of heart failure with preserved ejection fraction (HFpEF). Accordingly, a profound understanding of the underlying biomechanical mechanisms involved in DD is needed to elucidate all aspects of HFpEF. In this study, we have developed a computational model of DD by leveraging the power of an advanced one-dimensional arterial network coupled to a four-chambered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32822212
DOI: 10.1152/ajpheart.00172.2020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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