Article

Immunodominant NP105-113-B*0702 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

2021-07-27

Abstract excerpt

<title>Abstract</title> NP105-113-B*07:02 specific CD8+ T-cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis of NP105-113-B*07:02 specific T-cell clones and single cell sequencing were performed concurrently, with functional avidity and anti-viral efficacy assessed us...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cc3c8287-85d4-5657-80e6-5a76870479a0
DOI: 10.21203/rs.3.rs-734011/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunodominant NP105-113-B*0702 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 diseaseDOI 10.21203/rs.3.rs-734011/v1Read

An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 diseaseSemantic proximity Read

A unique cytotoxic CD4 + T cell‐signature defines critical COVID‐19Semantic proximity Read

Comprehensive longitudinal profiling of SARS-CoV-2-specific CD8 + T-cells reveal strong functional impairment and recognition bias as markers for disease severitySemantic proximity Read

Distinct CD8 + T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2 + PatientsSemantic proximity Read

A unique cytotoxic CD4+T cells signature defines critical COVID-19Semantic proximity Read

TCR signatures following SARS-CoV-2 infection correlate with clinical symptoms and post-acute sequelae of COVID-19Semantic proximity Read

High Precursor Frequency and Promiscuity in Αβ T Cell Receptor Pairing Underpin CD8+ T-Cell Responses to an Immunodominant SARS-CoV-2 Nucleocapsid EpitopeSemantic proximity Read

mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infectionSemantic proximity Read

Immune Features of COVID-19 Convalescent Individuals Revealed by a Single-cell RNA SequencingSemantic proximity Read

Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19Semantic proximity Read

CD8+ T cell clonotypes from prior SARS-CoV-2 infection predominate during the cellular immune response to mRNA vaccinationSemantic proximity Read

COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2Semantic proximity Read