Article

Interchromosomal segmental duplication drives translocation and loss of <i>P. falciparum</i> histidine-rich protein 3

2022-12-08

Abstract excerpt

<h4>ABSTRACT</h4> Most malaria rapid diagnostic tests (RDTs) detect Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and PfHRP3, but deletions of pfhrp2 and phfrp3 genes make parasites undetectable by RDTs. We analyzed 19,313 public whole-genome-sequenced P. falciparum field samples to understand these deletions better. Pfhrp2 deletion only occurred by chromosomal breakage with subsequent telomere heal...

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Literature Corpus work: cb76fd20-f607-5808-a1e7-56b84436fad6
DOI: 10.1101/2022.12.07.519189

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