Article
Lineage-Specific Expansion of Plasmodium falciparum Parasites With pfhrp2 Deletion in the Greater Mekong Subregion.
The Journal of infectious diseases - 1 Oct 2020
Gibbons Justin, Qin Junling, Malla Pallavi, Wang Zenglei, Brashear Awtum, Wang Chengqi, Miao Jun, Adams John H, Kim Kami, Jiang Rays, Cui Liwang
Abstract excerpt
Deletion of the pfhrp2 gene in Plasmodium falciparum can lead to false-negative rapid diagnostic test (RDT) results, constituting a major challenge for evidence-based malaria treatment. Here we analyzed the whole genome sequences of 138 P. falciparum clinical samples collected from the China-Myanmar boarder for pfhrp2 and pfhrp3 gene deletions. We found pfhrp2 and pfhrp3 deletions in 9.4% and 3.6% of samples,...
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