Shielded by the dead: how killed bacteria shape the dynamics and evolution of innate immunity

Abstract excerpt

The outcome of an infection is determined by the dynamic interplay between microbial growth and host immunity. During a bacterial infection, bacteria killed by innate immune effectors can accumulate as corpses in the extracelluar space, where they can continue to bind (and thus sequester) immune effectors. The impacts on infection outcomes of continued biochemical activity (“sponginess”) by the dead have been gene...

Topics

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• Bacterial Genetics and Biotechnology
• Bacterial Infections
• Clostridium difficile and Clostridium perfringens research
• Cytomegalovirus and herpesvirus research
• Escherichia coli research studies
• Immune responses and vaccinations
• Mathematical and Theoretical Epidemiology and Ecology Models
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

cb2abafb-7f52-5172-8d64-22eb16414f8f

DOI

10.64898/2026.02.05.704043