Article

Bioinformatic and literature assessment of toxicity and allergenicity of a CRISPR-Cas9 engineered gene drive to control the human malaria mosquito vector Anopheles gambiae

2022-12-06

Abstract excerpt

<h4>Background: </h4> Population suppression gene drive is currently being evaluated, including via environmental risk assessment (ERA), for malaria vector control. One such gene drive involves the dsxF CRISPRh transgene encoding (i) hCas9 endonuclease, (i) T1 guide RNA (gRNA) targeting the doublesex locus, and (iii) DsRed fluorescent marker protein, in genetically modified mosquitoes (GMMs). Problem formulation,...

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Literature Corpus work: caa8b378-e3b7-5534-ab80-95ee99137afa
DOI: 10.21203/rs.3.rs-2337461/v1

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