Article

Deep hybrid modeling of a HEK293 process: combining Long Short-Term Memory (LSTM) networks with first principles equations

2023-08-23

Abstract excerpt

In this paper, Long Short-Term Memory (LSTM) networks and multilayered feedforward neural networks (FFNNs) were combined with first principles equations in a hybrid workflow to describe human embryonic kidney 293 (HEK293) culture dynamics. Experimental data of 27 extracellular state variables in 20 fed-batch HEK293 cultures were collected in a parallel high throughput 250 mL cultivation system. The adaptive moment...

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Literature Corpus work: ca75f8e7-153a-55b6-bc69-c205f766a06b
DOI: 10.22541/au.169280650.01297299/v1

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