Article

Physiology-informed regularization enables training of universal differential equation systems for biological applications

2024-06-01

Abstract excerpt

Systems biology tackles the challenge of understanding the high complexity in the internal regulation of homeostasis in the human body through mathematical modelling. These models can aid in the discovery of disease mechanisms and potential drug targets. However, on one hand the development and validation of knowledge-based mechanistic models is time-consuming and does not scale well with increasing features in me...

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Literature Corpus work: 55c20035-2f34-5051-9a8c-f2b3ebb382a0
DOI: 10.1101/2024.05.28.596164

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