Article

Multifactorial remodeling of the cancer immunopeptidome by interferon gamma

2022-03-26

Abstract excerpt

IFNγ alters the immunopeptidome presented on HLA class I (HLA-I), and its activity on cancer cells is known to be important for effective immunotherapy responses. We performed proteomic analyses of untreated and IFNγ-treated colorectal cancer patient-derived organoids (PDOs) and combined this with transcriptomic and HLA-I immunopeptidomics data to dissect mechanisms that lead to remodeling of the immunopeptidome t...

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Literature Corpus work: ca39c194-925e-5081-829c-41deb83ea173
DOI: 10.1101/2022.03.23.485466

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