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Quantitative systems pharmacology modeling of avadomide-induced neutropenia enables virtual clinical dose and schedule finding studies

2021-04-29

Abstract excerpt

Avadomide is a cereblon E3 ligase modulator and a potent antitumor and immunomodulatory agent. Avadomide trials are challenged by neutropenia as a major adverse event and a dose-limiting toxicity. Intermittent dosing schedules supported by preclinical data provide a strategy to reduce frequency and severity of neutropenia, however the identification of optimal dosing schedules remains a clinical challenge. Quantit...

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Literature Corpus work
ca1872d2-48dd-5a42-9d53-4819a02c2818
DOI
10.1101/2021.04.28.438168
Open publication

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Quantitative systems pharmacology modeling of avadomide-induced neutropenia enables virtual clinical dose and schedule finding studiesDOI 10.1101/2021.04.28.438168
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