Article

Efficient identification of trait-associated loss-of-function variants in the UK Biobank cohort by exome-sequencing based genotype imputation

2021-08-13

Abstract excerpt

The large-scale open access whole-exome sequencing (WES) data of the UK Biobank ~200,000 participants is accelerating a new wave of genetic association studies aiming to identify rare and functional loss-of-function (LoF) variants associated with a broad range of complex traits and diseases, however the community is in short of stringent replication of new associations. In this study, we proposed to merge the WES...

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Literature Corpus work: ca0b86dd-0174-58fd-a90d-2ae1fed4d4fa
DOI: 10.1101/2021.08.12.456052

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