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Article

Asprosin Neutralizing Antibodies as a Treatment for Metabolic Syndrome

2020-09-16

Abstract excerpt

Recently, we discovered a new glucogenic and centrally-acting orexigenic hormone – asprosin. Asprosin is elevated in metabolic syndrome (MS) patients, and importantly, its genetic loss results in reduced appetite, leanness and robust insulin sensitivity, leading to protection from MS. Here we demonstrate that anti-asprosin monoclonal antibodies (mAbs) are a dual-effect pharmacologic therapy that targets the two ke...

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Literature Corpus work
c9bfaed2-2125-5be7-b305-3d13601ae0df
DOI
10.1101/2020.09.15.298489
Open publication

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Asprosin Neutralizing Antibodies as a Treatment for Metabolic SyndromeDOI 10.1101/2020.09.15.298489
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