LAMELLAR THICKNESS MEASUREMENTS IN NORMAL AND OSTEOGENESIS IMPERFECTA HUMAN BONE, with development of a method of automated thickness averaging to simplify quantitation

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Lamellar bone that forms in moderate and severe osteogenesis imperfecta (OI) is often composed of structurally irregular lamellae compared to those in normal bone. Polarization light microscopy (PLM) demonstrates lamellar bone well but has rarely been used for quantitative studies; information available on normal bone lamellae tends to be variable and studies specifically asses...

Topics

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• Bone and Bones
• Bone Density
• Collagen Type I
• Disease Models, Animal
• Genotype
• Mice
• Minerals
• Osteogenesis Imperfecta

Identifiers and source

Literature Corpus work

c9a07982-0aa2-5710-858e-29134949f11e

DOI

10.1101/2022.05.30.493917