Article

Effects of Sulforaphane in Ferroptosis, Apoptosis, and Senescence induced by Cigarette Smoke in Human Bronchial Epithelial Cells: a Mechanistic Study

2024-09-09

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Cigarette smoke (CS) is a leading risk factor for pulmonary diseases. It has been implicated that ferroptosis and apoptosis are involved in CS-induced lung senescence. Sulforaphane (SFN) is a phytochemical with anti-oxidative and anti-inflammatory effects. However, we investigated the effects of CS on oxidative damage, apoptosis, ferroptosis, and senescence in th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c8f39d56-5be6-5b76-8b36-25f2c6527d07
DOI: 10.21203/rs.3.rs-4887220/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effects of Sulforaphane in Ferroptosis, Apoptosis, and Senescence induced by Cigarette Smoke in Human Bronchial Epithelial Cells: a Mechanistic StudyDOI 10.21203/rs.3.rs-4887220/v1Read

R-phycocyanin from porphyra haitanensis attenuates apoptosis, ROS accumulation and cell cycle arrest induced by ameliorated cigarette smoke extract through AKT/MAPK/NF-κB signaling in human lung fbroblasts HFL1 cellsSemantic proximity Read

The Role of Ferroptosis in Bronchoalveolar Epithelial Cell Injury Induced by Cigarette Smoke ExtractSemantic proximity Read

Human alveolar epithelial cell injury induced by cigarette smoke.Semantic proximity Read

Antioxidant induces DNA damage, cell death and mutagenicity in human lung and skin normal cells.Semantic proximity Read

Cigarette smoke induces cellular senescence.Semantic proximity Read

Single-nucleus RNA Sequencing reveals the mechanism of cigarette smoke exposure on diminished ovarian reserve in miceSemantic proximity Read

Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosaSemantic proximity Read

Propyl gallate induces cell death in human pulmonary fibroblast through increasing reactive oxygen species levels and depleting glutathioneSemantic proximity Read

Understanding Lung Carcinogenesis from a Morphostatic Perspective: Prevention and Therapeutic Potential of Phytochemicals for Targeting Cancer Stem Cells.Semantic proximity Read

Quercetin relieves ferroptosis and M1 polarization in neutrophilic asthmatic mouse modelSemantic proximity Read

Cigarette smoke induces senescence in alveolar epithelial cells.Semantic proximity Read

Therapeutic effects of melatonin on the lungs of rats exposed to passive smokingSemantic proximity Read