Article

Generating Digital Twins with Multiple Sclerosis Using Probabilistic Neural Networks

2020-02-05

Abstract excerpt

Multiple Sclerosis (MS) is a neurodegenerative disorder characterized by a complex set of clinical assessments. We use an unsupervised machine learning model called a Conditional Restricted Boltzmann Machine (CRBM) to learn the relationships between covariates commonly used to characterize subjects and their disease progression in MS clinical trials. A CRBM is capable of generating digital twins, which are simulat...

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Literature Corpus work: c891d71b-6c7d-5385-8721-eef7d9a7acb5
DOI: 10.1101/2020.02.04.934679

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