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A novel multi-antigenic parapoxvirus-based vaccine demonstrates efficacy in protecting hamsters and non-human primates against SARS-CoV-2 challenge

2023-05-19

Abstract excerpt

<title>Abstract</title> <p>The next generation of COVID-19 vaccines needs to broaden the antigenic repertoire to improve breadth of immune response and efficacy against emerging variants of concern. This study describes a new parapoxvirus-based vector (ORFV) as a platform to design a multi-antigenic vaccine targeting SARS-CoV-2 spike and nucleocapsid antigens. Two vaccine candidates were engineered, one expressin...

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Literature Corpus work
c83543c1-c835-5abc-9647-0a4c095a6db3
DOI
10.21203/rs.3.rs-2832501/v1
Open publication

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