Article

Molecular Docking Appraisal of Dysphania ambrosioides Phytochemicals as Potential Inhibitor of a Key Triple-negative Breast Cancer Driver Gene

2023-04-27

Abstract excerpt

<title>Abstract</title> <p>Triple-negative breast cancer (TNBC) is a lethal and aggressive breast cancer subtype. It is characterized by the deficient expression of the three main receptors implicated in breast cancers, making it unresponsive to hormone therapy. Hence, an existing need to develop a targeted molecular therapy for TNBC. The PI3K/AKT/mTOR signaling pathway mediates critical cellular processes, inclu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c82337b5-c87d-5071-8cc1-d54331f571c0
DOI: 10.21203/rs.3.rs-2854790/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular Docking Appraisal of Dysphania ambrosioides Phytochemicals as Potential Inhibitor of a Key Triple-negative Breast Cancer Driver GeneDOI 10.21203/rs.3.rs-2854790/v1Read

Exploring Natural Compound Libraries for Breast Cancer Targets: An In Silico StudySemantic proximity Read

Integrated Network Pharmacology Reveal New Key Curcumin-Binding Targets in Triple-Negative Breast CancerSemantic proximity Read

Molecular docking and MD simulation approach to identify potential phytochemical lead molecule against triple negative breast cancerSemantic proximity Read

Molecular targets and therapies associated with poor prognosis of triple‑negative breast cancer (Review)Semantic proximity Read

Compounds from diverse natural origin against triple‐negative breast cancer: A comprehensive reviewSemantic proximity Read

Multi-Scale Computational Investigation of Heliotropium indicum Phytochemicals as Multi-Target Therapeutics Against Breast Cancer: Integration of Network Pharmacology, Molecular Dynamics with Free- Energy Calculation, and Machine LearningSemantic proximity Read

3d Pharamacophore Model, Virtual Screening, Binding Affinity and Molecular Dynamics Studies of Potential Anticancerous Compounds Against Mammalian Target RapamycinSemantic proximity Read

Syringin Exerts Anti-Breast Cancer Effects Through PI3K-AKT and EGFR-RAS-RAF PathwaysSemantic proximity Read

The potential mechanism of pachymic acid in triple-negative breast cancer: a network pharmacology and vitro experimentsSemantic proximity Read

Research on therapeutic clinical trials including immunotherapy in Triple- negative Breast cancer: A bibliometric analysisSemantic proximity Read

Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review.Semantic proximity Read

Systems biology-based discovery of a potential Atg4B agonist (Flubendazole) that induces autophagy in breast cancerSemantic proximity Read