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Exploration of COX-Like Activity in Wild-Type gp63 Recombinant Protein from Leishmania mexicana; Identification of Orthologous Proteins in Clinically Significant Parasites, and Investigation of Arachidonic Acid Binding Sites

2024-07-31

Abstract excerpt

Recently, we published that the monoclonal antibody (D12 mAb) recognizes gp63 of L. mexicana, it is responsible for COX activity. This D12 mAb exhibited cross-reactivity with Trypanosoma cruzi, Entamoeba histolytica, Acanthamoeba castellanii, and Naegleria fowleri. COX activity assays performed in these parasites suggested the potential presence of such enzymatic activity. In our investigation, we confirmed that w...

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Literature Corpus work: c7a5a85b-50b0-58f5-ac36-ddf7e2012aa0
DOI: 10.20944/preprints202407.2496.v1

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Exploration of COX-Like Activity in Wild-Type gp63 Recombinant Protein from Leishmania mexicana; Identification of Orthologous Proteins in Clinically Significant Parasites, and Investigation of Arachidonic Acid Binding SitesDOI 10.20944/preprints202407.2496.v1Read

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