Mutational and functional analysis of the Leishmania surface metalloproteinase GP63: similarities to matrix metalloproteinases.

doi:10.1017/s0031182000075697

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Article

Mutational and functional analysis of the Leishmania surface metalloproteinase GP63: similarities to matrix metalloproteinases.

Parasitology - 1 Jan 1994

McMaster W R, Morrison C J, MacDonald M H, Joshi P B

Abstract excerpt

The major surface glycoprotein of Leishmania, referred to as GP63, is a zinc metalloproteinase of 63,000 M(r) present on promastigotes and amastigotes from diverse species of Leishmania. GP63 shares several characteristics with the members of the matrix metalloproteinase family including degradat...

Topics

Amino Acid Sequence
Animals
Binding Sites
Conserved Sequence
Genes, Protozoan
Humans
Leishmania
Metalloendopeptidases
Molecular Sequence Data
Mutation

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