Article

High BRCA1 Gene Expression Increases the Risk of Early Onset Distant Metastasis in ER+ Breast Cancers

2020-12-01

Abstract excerpt

<h4>Background: </h4> More than 30% of ER + breast cancer patients developed distant metastasis after adjuvant tamoxifen therapy. It has been shown that decreased BRCA1 protein function confers anti-estrogen “resistance.” Since the functional status of BRCA1 protein auto-regulates its own gene expression, BRCA1 transcript level should possibly be used to assess its active protein levels. Thus, it is interesting to...

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Literature Corpus work: c79dffdb-0fb3-581e-a1fd-00e1e9f5c5e4
DOI: 10.21203/rs.3.rs-116024/v1

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