Article

Interspecies Functional Divergence: The Microbiome’s Role in FLOT Response e Across Gastric Cancer Subtypes

2025-09-17

Abstract excerpt

<h4>Background</h4> Gastric adenocarcinoma exhibits marked molecular and histological heterogeneity, which is reflected in distinct patterns of progression, therapeutic response, and prognosis. Although the FLOT regimen (5-fluorouracil, leucovorin, oxaliplatin, and docetaxel) represents the current standard for perioperative chemotherapy, its systemic effects on the tumor microenvironment, including the associate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c732c318-42c6-5895-b970-188dc1202db4
DOI: 10.1101/2025.09.13.676018

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interspecies Functional Divergence: The Microbiome’s Role in FLOT Response e Across Gastric Cancer SubtypesDOI 10.1101/2025.09.13.676018Read

Integrated multi-omics profiling reveals phenotype- and tissue-specific host-microbiota interactions in paired tumor and peritumoral tissues of advanced gastric cancer patients from Northwest China.Semantic proximity Read

Gastric Cancer Heterogeneity and Clinical OutcomesSemantic proximity Read

Intratumoral microbiome is associated with gastric cancer prognosis and therapy efficacySemantic proximity Read

Mucin-microbiome signatures shape the tumor microenvironment in gastric cancer.Semantic proximity Read

Genetic mutation and tumor microbiota determine heterogenicity of tumor immune signature: Evidence from gastric and colorectal synchronous cancers.Semantic proximity Read

Molecular Characterization of the Human Stomach Microbiota in Gastric Cancer PatientsSemantic proximity Read

Single-cell transcriptomic profiling uncovers cellular complexity and microenvironment in gastric tumorigenesis associated with Helicobacter pyloriSemantic proximity Read

Characterization and Diagnostic Value of Oral Microbiota Across Different Progression Stages of Gastric CancerSemantic proximity Read

Tumor microenvironment interplay amid microbial community, host gene expression and pathological features elucidates cancer heterogeneity and prognosis riskSemantic proximity Read

Single-cell RNA sequencing revealed the T cell heterogeneity and exhaustion subsets of Helicobacter pylori-induced gastritis - cancer transformationSemantic proximity Read

Single cell genomic characterization reveals the cellular reprogramming of the gastric tumor microenvironmentSemantic proximity Read

The relationship between the gastric cancer microbiome and clinicopathological factors: a metagenomic investigation from the 100,000 genomes project and The Cancer Genome AtlasSemantic proximity Read