Article
Mucin-microbiome signatures shape the tumor microenvironment in gastric cancer.
Microbiome - 21 Apr 2023
Oosterlinck Baptiste, Ceuleers Hannah, Arras Wout, De Man Joris G, Geboes Karen, De Schepper Heiko, Peeters Marc, Lebeer Sarah, Skieceviciene Jurgita, Hold Georgina L, Kupcinskas Juozas, Link Alexander, De Winter Benedicte Y, Smet Annemieke
Abstract excerpt
BACKGROUND AND AIMS: We aimed to identify mucin-microbiome signatures shaping the tumor microenvironment in gastric adenocarcinomas and clinical outcomes. METHODS: We performed high-throughput profiling of the mucin phenotypes present in 108 gastric adenocarcinomas and 20 functional dyspepsia cases using validated mucin-based RT-qPCRs with subsequent immunohistochemistry validation and correlated the data with...
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