Article

Mixed Features and Symptom Trajectories in Adolescent Major Depressive Disorder: A Naturalistic Cohort Study

2026-07-28

Abstract excerpt

<title>Abstract</title> <p> The clinical significance of the DSM-5 "with mixed features" specifier in adolescent major depressive disorder (MDD)—here termed MDD with mixed features (DMF)—remains uncertain, and its longitudinal course has rarely been examined. In a two-site naturalistic cohort of adolescents with early-course MDD enrolled between May 2024 and April 2025, we tested whether DMF status was associate...

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Literature Corpus work: c72ab87b-313a-55f5-b3d0-b765b7a1c05d
DOI: 10.21203/rs.3.rs-10346043/v1

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