Article
Integrative multi-omics reveals microbial genomic variants driving altered host-microbe interactions in autism spectrum disorder.
Cell reports. Medicine - 20 Jan 2026
Chen Wanning, Wang Xinjun, Zhu Ruixin, Gao Wenxing, Tao Liwen, Yang Rong, Wei Qing, Zhang Yiming, Gong Yujiao, Zhong Hui, Huang Linsheng, Zhu Xinyue, Yang Yuwei, Zhang Linjuan, Wan Lin, Yang Guang, Li Yan, Jiao Na, Wang Jifeng, Qin Huanlong, Zhu Lixin
Abstract excerpt
Emerging evidence links the gut microbiome to autism spectrum disorder (ASD), yet the role of microbial genomic variation remains underexplored. We generated a large-scale metagenomic and metabolomic dataset from over 1,100 children, integrating public datasets, to characterize ASD-associated microbial changes. We identified 35 species, 213 genes, 28 pathways, and 99 metabolites, alongside 1,369 single-nucleotide...
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