Article

Stochastic model of Alzheimer’s Disease progression using two-state Markov chains

2023-07-01

Abstract excerpt

In 2016, Hao and Friedman developed a deterministic model of Alzheimer’s disease progression using a system of partial differential equations. This model describes the general behavior of the disease, however, it does not incorporate the molecular and cellular stochasticity intrinsic to the underlying disease processes. Here we extend the Hao and Friedman model by modeling each event in disease progression as a st...

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Literature Corpus work: c53a7292-c680-5958-a1b5-a0e79f16a010
DOI: 10.1101/2023.06.29.547071

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