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Article

Computable cause-and-effect models of healthy and Alzheimer's disease states and their mechanistic differential analysis.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2015

Kodamullil Alpha Tom, Younesi Erfan, Naz Mufassra, Bagewadi Shweta, Hofmann-Apitius Martin

Abstract excerpt

INTRODUCTION: The discovery and development of new treatments for Alzheimer's disease (AD) requires a profound mechanistic understanding of the disease. Here, we propose a model-driven approach supporting the systematic identification of putative disease mechanisms. METHODS: We have created a model for AD and a corresponding model for the normal physiology of neurons using biological expression language to...

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PMID: 25849034
DOI: 10.1016/j.jalz.2015.02.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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