Article

The transcription factor HIF2α partakes in the differentiation block of acute myeloid leukemia

2022-06-15

Abstract excerpt

<title>Abstract</title> <p>Differentiation arrest along the myeloid lineage is a defining feature of acute myeloid leukemia (AML), but its molecular determinants remain poorly defined. Pharmacological removal of the differentiation block leads to leukemia eradication in acute promyelocytic leukemia (APL) patients but has not yet been successfully translated to non-APL AMLs. Here, by investigating the function of...

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Literature Corpus work: c481da45-1922-5cd6-81c2-fc5a0fad34ab
DOI: 10.21203/rs.3.rs-1719682/v1

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