Article
Targeting IL-6 reduces IgM levels and tumor growth in Waldenström macroglobulinemia
2019-04-02
Abstract excerpt
The tumor microenvironment (TME) plays an important role in cancer and plays a role in resistance to therapy. In Waldenström macroglobulinemia (WM), a B-cell malignancy characterized by the overproduction of a monoclonal IgM protein, the TME plays an important role in WM biology by secreting cytokines that promote malignant phenotype. In previous work, we have shown that TME-IL-6 promotes WM cell growth and IgM se...
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Identifiers and source
- Literature Corpus work
- c3ebc235-eafc-50ae-ae46-ddbbed5c1fbf
- DOI
- 10.1101/592642