Flagellin in the human gut microbiome is a diet-adjustable adjuvant for vaccination

Abstract excerpt

<h4>ABSTRACT</h4> The intestinal microbiota is thought to modulate immune responsiveness to vaccines. Human studies on this topic, however, have yielded inconsistent results 1,2 . We hypothesized that the microbiome would influence innate immune responses, and thus vaccine reactogenicity, more directly than vaccine immunogenicity. To test this, we established the µHEAT (Microbial-Human Ecology And Temperature) s...

Topics

Open a Topic to create a Post that cites this publication.

• Clinical Trials as Topic
• Clostridium difficile and Clostridium perfringens research
• Gene-Environment Interaction
• Gut microbiota and health
• Immune System
• Microbiota
• Models, Immunological
• Viral gastroenteritis research and epidemiology

Identifiers and source

Literature Corpus work

c30125fb-1663-5a17-9e20-8c69b2d8c2f1

DOI

10.1101/2025.02.21.639485