Article

Multi-Timescale Neural Adaptation Failure as a Mechanistic Signature of Major Depression

2025-12-18

Abstract excerpt

Major depression (MD) is usually characterized in terms of momentary abnormalities, such as negative bias or emotional blunting, derived from paradigms that measure only the first response to a stimulus. Yet depressive experience in daily life is repetitive and cumulative. Here we test the hypothesis that a failure of neural adaptation across repetitions is a core feature of MD. Using a repeated negative-stimulus...

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Literature Corpus work: c14f7cc6-d977-5d18-b740-2b3b13cb77fd
DOI: 10.64898/2025.12.16.694510

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