Back to search

Article

Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy

2023-07-15

Abstract excerpt

Here we report a novel suite of magnetogenetic tools, based on a single anti-ferritin nanobody-TRPV1 receptor fusion protein, which regulated neuronal activity when exposed to magnetic fields. AAV-mediated delivery of a floxed nanobody-TRPV1 into the striatum of adenosine 2a receptor-cre driver mice resulted in motor freezing when placed in an MRI or adjacent to a transcranial magnetic stimulation (TMS) device. Fu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c1254376-7839-5856-86fa-a3d7af759fed
DOI
10.1101/2023.07.13.548699
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene TherapyDOI 10.1101/2023.07.13.548699
Non-invasive in vivo bidirectional magnetogenetic modulation of pain circuitsSemantic proximity
Magnetogenetic cell activation using endogenous ferritinSemantic proximity
Remote magnetomechanical neuromodulation uncovers a novel therapeutic mechanism for alleviating Parkinsonian symptoms in freely moving miceSemantic proximity
Ferrimagnetic Vortex Nanorings Facilitate Efficient and Safe Deep-Brain Magnetothermal Stimulation in Freely Moving MiceSemantic proximity
Regulating Human T Lymphocytes Through Magnetogenetic ToolsSemantic proximity
Magnetogenetic stimulation inside MRI induces spontaneous and evoked changes in neural circuits activity in ratsSemantic proximity
Magnetoelectric Nanodiscs Enable Wireless Transgene-Free NeuromodulationSemantic proximity
Micromagnetic Stimulation (μMS) Controls Dopamine Release: An <i>in vivo</i> Study Using WINCS <i>Harmoni</i>Semantic proximity
Hydrogen-bonded organic framework nanotransducers enabled sono-optogenetics for Parkinsonian ratsSemantic proximity
Magnetogenetic closed-loop reduction of seizure activity in a rat model of epilepsySemantic proximity
Exploring GPCR-mediated optogenetic modulation of seizure network in a pig model of Temporal Lobe EpilepsySemantic proximity
Manganese Accumulation for Genetically Induced Contrast (MAGIC) MRI in the brain across speciesSemantic proximity
Select a neighboring publication to make it the new centre.