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Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD

12 Feb 2016

Abstract excerpt

Hexanucleotide repeat expansions in C9orf72 are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) (c9ALS/FTD). Unconventional translation of these repeats produces dipeptide repeat proteins (DPRs) that may cause neurodegeneration. We performed a modifier screen in Drosophila and discovered a critical role for importins and exportins, Ran-GTP cycle regulators,...

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PMID: 26869068
DOI: 10.1038/srep20877

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Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTDPMID 26869068Read ↗

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALSSemantic proximity Read ↗

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