Article

Network Medicine-Based Approach Reveals Cyclosporine and Selinexor Drug Combination as an Effective Therapy against SARS-COV-2

2024-03-28

Abstract excerpt

The proliferation of SARS-COV-2 through enhanced viral replication and its subsequent triggering of cytokine storm, are some of the hallmark phenotypes in severe COVID-19 patient cases. Cyclosporine, an immunosuppressant drug and Selinexor, an inhibitor of nuclear transporter protein, both have been successfully demonstrated to be effective against SARS-COV-2 infection by targeting those functions individually. Ho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c0fe1ce1-b252-5871-aa40-af281472caa4
DOI: 10.20944/preprints202403.1708.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Network Medicine-Based Approach Reveals Cyclosporine and Selinexor Drug Combination as an Effective Therapy against SARS-COV-2DOI 10.20944/preprints202403.1708.v1Read

Designing a Network Proximity-Based Drug Repurposing Strategy for COVID-19Semantic proximity Read

A Connectivity Map-Based Drug Repurposing Study and Integrative Analysis of Transcriptomic Profiling of SARS-CoV-2 InfectionSemantic proximity Read

A systems‐level study reveals host‐targeted repurposable drugs against SARS‐CoV‐2 infectionSemantic proximity Read

A connectivity map-based drug repurposing study and integrative analysis of transcriptomic profiling of SARS-CoV-2 infectionSemantic proximity Read

Network-Based Identification and Experimental Validation of Drug Candidates Toward SARS-CoV-2 via Targeting Virus–Host InteractomeSemantic proximity Read

Lung Disease Network Reveals the Impact of Comorbidity on SARS-CoV-2 Infection and Opportunities of Drug RepurposingSemantic proximity Read

Identifying potential drug targets and candidate drugs for COVID-19: biological networks and structural modeling approachesSemantic proximity Read

Network bioinformatics analysis provides insight into drug repurposing for COVID-19Semantic proximity Read

Transcriptome and SARS-CoV-2 biological network directed analysis for better therapeutic developmentSemantic proximity Read

Connecting the dots: applications of network medicine in pharmacology and disease.Semantic proximity Read

In silico synergistic drug repurposing for combating novel coronavirus (COVID-19) outbreaksSemantic proximity Read

Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19Semantic proximity Read