Article

Burden of tumor mutations, neoepitopes, and other variants are dubious predictors of cancer immunotherapy response and overall survival

2019-06-08

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Tumor mutational burden (TMB, the quantity of aberrant nucleotide sequences a given tumor may harbor) has been associated with response to immune checkpoint inhibitor therapy and is gaining broad acceptance as a result. However, TMB harbors intrinsic variability across cancer types, and its assessment and interpretation are poorly standardized. <h4>Methods</h4> Using a stan...

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Literature Corpus work: c0b3a2ec-6ab7-50b8-889d-eb9854b53454
DOI: 10.1101/665026

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