Article

Reference data based insights expand understanding of human metabolomes

2020-07-11

Abstract excerpt

<h4>Summary</h4> The human metabolome has remained largely unknown, with most studies annotating ∼10% of features. In nucleic acid sequencing, annotating transcripts by source has proven essential for understanding gene function. Here we generalize this concept to stool, plasma, urine and other human metabolomes, discovering that food-based annotations increase the interpreted fraction of molecular features 7-fol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c07c9b8b-fa1d-594e-9330-0506f804b24a
DOI: 10.1101/2020.07.08.194159

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reference data based insights expand understanding of human metabolomesDOI 10.1101/2020.07.08.194159Read

MeNu GUIDE - a metabolite nutrition graph to uncover interactions with disease etiologySemantic proximity Read

Metabolic individuality: Limitations, challenges, and potential for clinical utility.Semantic proximity Read

Plasma metabolomic profiles enhance precision medicine for volunteers of normal healthSemantic proximity Read

Suggesting disease associations for overlooked metabolites using literature from metabolic neighboursSemantic proximity Read

An interactive web application for exploring human plasma and fibroblast metabolomics data from patients with inborn errors of metabolismSemantic proximity Read

Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkersSemantic proximity Read

The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and diseaseSemantic proximity Read

AMON: Annotation of metabolite origins via networks to better integrate microbiome and metabolome dataSemantic proximity Read

NMR-based metabolomics in human disease diagnosis: applications, limitations, and recommendationsSemantic proximity Read

Personalized beyond Precision: Designing Unbiased Gold Standards to Improve Single-Subject Studies of Personal Genome Dynamics from Gene ProductsSemantic proximity Read

Returning Genomic Dietary Data to Participants by Translating Stool DNA into a Personal Food ProfileSemantic proximity Read

Protocol for genome-wide association study of human blood metabolites.Semantic proximity Read