Article

Cholesterol sulfate prevents maternal–fetal conflict by locally modulating immune reactivity

2024-10-15

Abstract excerpt

Although placental mammals are at high risk of maternal–fetal immune conflict, it is unclear how the semi-allogeneic fetus avoids rejection. Cholesterol sulfate (CS) is a bioactive metabolite that inhibits leukocyte migration and activation. This study investigated the roles and cells associated with CS in pregnant mice and humans. CS was sequentially produced by maternal-derived endometrial cells and fetal-derive...

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Literature Corpus work: bff6441d-c14c-5a19-87c1-80e25729f0a1
DOI: 10.1101/2024.10.11.617779

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