Article

Limited discriminative utility of resting-state heart rate variability for chronic pain–depression–anxiety comorbidity subtypes: an exploratory SHAP-based machine-learning analysis

2026-06-28

Abstract excerpt

<title>Abstract</title> <p>Background Chronic pain frequently co-occurs with depression and anxiety, but whether different chronic pain–depression–anxiety comorbidity (CPDA) subtypes can be differentiated using objective physiological indicators remains unclear. Heart rate variability (HRV) reflects autonomic nervous system regulation and has been widely examined in pain and emotional disorders. This exploratory...

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Literature Corpus work: bf789e04-7adb-5cd9-9bd2-4d0fd3b772ff
DOI: 10.21203/rs.3.rs-9991884/v1

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