Article

Episodic memory retrieval with increasing task demand: Associations with age, <i>APOE4</i> genotype, and Alzheimer’s disease pathology

2026-01-30

Abstract excerpt

<h4>BACKGROUND</h4> Episodic memory declines early with aging, reflecting reduced neural resources and diminished memory specificity. However, few studies have created a cognitive challenge with multiple levels of task demand to investigate this early subtle decline. Furthermore, it is unclear whether the genetic Alzheimer’s disease risk factor APOE4 and early Alzheimer’s pathology constrain the neural resources...

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Literature Corpus work: bf6dbf72-866a-5ec9-bae9-2c056fcc9cde
DOI: 10.64898/2026.01.30.26344953

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