Article

Introduction of single nucleotide variations into the promoter region of the mouse kidney anion exchanger 1 gene downstream of a TATA box changes its transcriptional activity

2017-10-04

Abstract excerpt

(Introduction) Distal renal tubular acidosis (dRTA) is characterized by an impairment of urine acidification and can be caused by variations in genes functioning in α-intercalated cells such as anion exchanger 1 (AE1). AE1 encodes the Cl - /HCO3 - exchanger in erythrocytes (eAE1) and α-intercalated cells (kAE1). We previously reported that in human erythroid intron 3 containing the promoter region of human kAE1,...

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Literature Corpus work: be998f9e-ebbb-50ac-8547-bb01b4e1e07c
DOI: 10.1101/198457

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