Article

In vivo directed evolution of AAV in the primate retina

2019-11-20

Abstract excerpt

Efficient AAV-mediated gene delivery remains a significant obstacle to effective retinal gene therapies. Here, we apply directed evolution – guided by deep sequencing and followed by direct in vivo secondary selection of high-performing vectors with a GFP-barcoded library – to create AAV viral capsids with new capabilities to deliver genes to the outer retina in primates. A replication incompetent library, produc...

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Identifiers and source

Literature Corpus work: 5f15da39-1abb-514b-be95-967f877036e6
DOI: 10.1101/847459

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