Article

Inflammation-driven JAK/STAT pathway activation is associated with downregulation of Fkrp expression in mouse skeletal muscle

2026-06-02

Abstract excerpt

<title>Abstract</title> <p> Introduction: Fukutin-related protein (FKRP) is essential for α-dystroglycan (αDG) glycosylation and sarcolemmal stability. Pathogenic variants in FKRP cause secondary dystroglycanopathies such as Limb-Girdle Muscular Dystrophy R9 (LGMDR9), yet the mechanisms regulating FKRP expression remain poorly understood. Methods C57BL/6J mice received intramuscular injections of escalating do...

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Literature Corpus work: be70e9c4-8ed1-5bcc-ae19-4a610f48bcca
DOI: 10.21203/rs.3.rs-9645975/v1

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