Article

An engineered serum albumin-binding AAV9 capsid achieves improved liver transduction after intravenous delivery in mice

2019-07-08

Abstract excerpt

<h4>ABSTRACT</h4> Recombinant adeno-associated viral (AAV) vectors are frequently used to deliver nucleic acids for in vivo applications and are currently the leading platform for therapeutic gene delivery in gene therapy clinical trials. Presently, there is a need for improved AAV vectors with optimized transduction efficiency in target tissues. In these studies, an engineered albumin-binding consensus domain (A...

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Literature Corpus work: 8e37b823-9346-5905-9fef-645927ba3783
DOI: 10.1101/694513

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