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Rational Design of AAV-rh74, AAV3B, and AAV8 with Limited Liver Targeting

28 Oct 2023

Abstract excerpt

Recombinant adeno-associated viruses (rAAVs) have become one of the leading gene therapies for treating a variety of diseases. One factor contributing to rAAVs' success is the fact that a wide variety of tissue types can be transduced by different serotypes. However, one commonality amongst most serotypes is the high propensity for liver transduction when rAAVs are administered peripherally. One of the few...

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PMID: 38005848
DOI: 10.3390/v15112168

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