Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Post-transcriptional modification of spliceosomal RNAs is normal in SMN-deficient cells

28 Nov 2011

Abstract excerpt

The survival of motor neuron (SMN) protein plays an important role in the biogenesis of spliceosomal snRNPs and is one factor required for the integrity of nuclear Cajal bodies (CBs). CBs are enriched in small CB-specific (sca) RNAs, which guide the formation of pseudouridylated and 2'-O-methylated residues in the snRNAs. Because SMN-deficient cells lack typical CBs, we asked whether the modification of internal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neurogenetic and Muscular Disorders Research
Share to RNA Research and Splicing

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22124016
DOI: 10.1261/rna.030106.111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Post-transcriptional modification of spliceosomal RNAs is normal in SMN-deficient cellsPMID 22124016Read ↗

SMN Is Essential for the Biogenesis of U7 Small Nuclear Ribonucleoprotein and 3′-End Formation of Histone mRNAsSemantic proximity Read ↗

RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent intronsSemantic proximity Read ↗

SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damageSemantic proximity Read ↗

U1 snRNP-Specific U1C Acts as the Gatekeeper of the Survival of Motor Neurons (SMN) Complex in snRNP BiogenesisSemantic proximity Read ↗

Methylation at nucleotide C <sup>62</sup> in spliceosomal RNA U6 alters mRNA splicing which is important for embryonic developmentSemantic proximity Read ↗

SnoRNA guide activities – real and ambiguousSemantic proximity Read ↗

Biology and clinical relevance of noncoding sno/scaRNAs.Semantic proximity Read ↗

Impaired minor tri-snRNP assembly generates differential splicing defects of U12-type introns in lymphoblasts derived from a type I SMA patientSemantic proximity Read ↗

Survival motor neuron protein regulates stem cell division, proliferation, and differentiation in Drosophila.Semantic proximity Read ↗

Localization of modified nucleotides in Schizosaccharomyces pombe spliceosomal small nuclear RNAs: modified nucleotides are clustered in functionally important regions.Semantic proximity Read ↗

Minor snRNA gene delivery improves the loss of proprioceptive synapses on SMA motor neuronsSemantic proximity Read ↗

TGS1 controls snRNA 3’ end processing, prevents neurodegeneration and ameliorates <i>SMN</i> -dependent neurological phenotypes in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.