Article

A scalable genetic tool for the functional analysis of the signal recognition particle.

2024-08-24

Abstract excerpt

Mutations in the SRP54 gene are linked to the pathophysiology of severe congenital neutropenia (SCN). SRP54 is a key protein comprising one of the six protein subunits of the signal recognition particle responsible for co-translational targeting of proteins to the ER; mutations in SRP54 disrupt this process. Crystal structures and biochemical characterization of a few SRP54 mutants provide insights into how S...

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Literature Corpus work: bb4bcf1a-430c-59b9-8782-dcd2bd88492f
DOI: 10.22541/au.172445815.56649297/v1

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