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Article

Cellular Traffic Jam and Disease Due to Mutations in SRP54.

Structure (London, England : 1993) - 7 Jan 2021

Weichenrieder Oliver

Abstract excerpt

In this issue of Structure, Juaire et al. use X-ray crystallography, biophysical tools, and cell-based assays to investigate disease-associated variants of the SRP54 GTPase and to demonstrate that defects in SRP-mediated protein secretion can explain phenotypes of severe neutropenia with Shwachman-Diamond-syndrome-like symptoms.

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Identifiers

PMID: 33417891
DOI: 10.1016/j.str.2020.12.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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